• Host cell invasion by tachyzoites relies on the

  2020-10-20

  

  Host cell invasion by tachyzoites relies on the secretion of numerous secretory proteins and plays a crucial role in maintaining infection [6]. ESA released by tachyzoites are highly immunogenic and induce either antibody-dependent or cell-mediated protective immunity [11], [44], [45]. To investigat

• Lately using receptor TM peptides

  2020-10-20

  

  Lately, using receptor TM peptides, BiFC and PLA experiments, we have also obtained experimental evidence for the tetrameric structure of A1R–D1R, which explains the canonical interaction on Gi and Gs, respectively (Fig. 2). We have demonstrated for the first time the presence of this heterotetramer

• For the SAR optimization of the right hand side it

  2020-10-20

  

  For the SAR optimization of the right hand side, it was decided to explore the inclusion of the key carboxylic Macitentan moiety present in the original DGAT-1 inhibitors from . Analogs were constructed by the synthetic routes outlined in , . In , the methylene-oxy linker was introduced by condensat

• br Materials and methods br Results br Discussion In this

  2020-10-19

  

  Materials and methods Results Discussion In this study, we investigated two novel candidate therapeutics, the related CRM1-inhibiting SINEs KPT-185 and KPT-276, in treatment of NHL. The results showed that KPT-185 induced growth inhibition, cell-cycle arrest, and apoptosis in tumor Telotris

• Our results on the acute effects of

  2020-10-19

  

  Our results on the acute effects of THC on resting state JTC-801 function are in line with previous neuroimaging findings. Increased perfusion after THC administration in insular and prefrontal regions has previously been reported in smaller samples (Mathew et al., 1997, Mathew et al., 2002, van He

• Introduction The physiological significance of hypoxia is un

  2020-10-19

  

  Introduction The physiological significance of hypoxia is undisputed, although largely over looked in the cancer therapeutics field focused on DNA-damage induced by ionizing radiation or drug treatment. Regions of hypoxia occur during a range of diverse biological situations including embryogenesis

• Therefore the SPH algorithm in AUTODYN D was

  2020-10-19

  

  Therefore, the SPH algorithm in AUTODYN-3D™ was used to simulate the experiment in Ref. [5] to verify the credibility of the numerical simulation method by results that could be measured accurately. Then the verified numerical simulation method was used to simulate BAD generated by RHA subjected to

• Cy5 NHS ester(Et) br Discussion EFTs are sarcomas

  2020-10-19

  

  Discussion EFTs are sarcomas with almost undifferentiated histologic features, consequently their differentiation from other small, blue, round cell tumors may be difficult. Substantial intracellular Cy5 NHS ester(Et) on PAS stain is a useful diagnostic feature. The addition of CD99 and FLI1 immu

• Binding affinity was measured by a scintillation proximity b

  2020-10-19

  

  Binding affinity was measured by a scintillation proximity binding assay using [H]4-OHT (ERRγ) or [H]estradiol (ERα/β) as radioligand. In all cases, the ERβ affinity was not significantly different from ERα. Compounds were compared to , which showed high affinity for both receptors and moderate (six

• It is believed that emphysema in smokers is

  2020-10-19

  

  It is believed that emphysema in smokers is mediated by proteases released from inflammatory Dimethyl Fumarate that cause destruction of the extracellular matrix in alveolar septa [1]. Metalloprotease-12 is mainly released by macrophages and is considered the enzyme responsible for emphysematous les

• Although enantioselective accumulation of metalaxyl

  2020-10-19

  

  Although enantioselective accumulation of metalaxyl in organisms is an integrated outcome of bio-process including absorption, transportation, and transformation, it is observed in our study that catalysis of CYP450 may lead to the enantioselective accumulation of metalaxyl. However, the mechanisms

• In conclusion our findings demonstrated that S

  2020-10-19

  

  In conclusion, our findings demonstrated that S1PC augments HMOX1 expression in a NO-dependent manner, and its effects are associated with the enhancement of BACH1 degradation. In addition, S1PC and NO potentially degrade BACH1 based on the observation that nuclear degradation of BACH1 differs from

• Compounds were synthesized using a

  2020-10-19

  

  Compounds were synthesized using a facile 8-step convergent synthesis ( and ). Briefly, (Boc)cyclen (compound ) was coupled using TBTU to Fmoc- or Cbz-protected amino alkyl acids (–), followed by deprotection using 20% piperidine in DMF, or H on Pd/C, respectively (–) (). Deprotected linkers were co

• br Phenotypic responses alkylation induced

  2020-10-17

  

  Phenotypic responses: alkylation-induced cell death and mutagenesis E. coli alkB mutants were isolated in a screen for strains specifically sensitive to the cytotoxicity of MMS but not UV-irradiation. This was the first indication that the AlkB protein is a primary cellular defence against alkyla

• br Introduction Diacylglycerol kinase DGK is a lipid metabol

  2020-10-17

  

  Introduction Diacylglycerol kinase (DGK) is a lipid-metabolizing enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic rki (PA) [[1], [2], [3], [4]]. DG and PA act as lipid second messengers in a wide variety of biological processes. Ten DGK isozymes (α, β, γ, δ, η, κ, ε, ζ, ι,

14780 records 708/986 page Previous Next First page 上5页 706707708709710 下5页 Last page