• kras-pdeδ pathway br Materials and methods br Results and di

  2020-04-15

  

  Materials and methods Results and discussion Conclusions Data about the ability of non-conventional ligands to operate class-A GPCRs have been accumulating. Specifically, increasing evidence indicates that oxysterols, oxidized derivatives of cholesterol, are involved in many activities that

• Downregulation of tumor suppressors is a

  2020-04-15

  

  Downregulation of tumor suppressors is a major factor that leads to tumorigenesis. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a common tumor suppressor, the g protein coupled receptors of which is often downregulated or even absent in the majority of human cancers, functions as

• In this study Oncomine GEO and TCGA

  2020-04-15

  

  In this study, Oncomine, GEO and TCGA databases were used to analyze the expression of UBE2S gene in HCC and normal liver tissues to determine the relationship between UBE2S expression and prognosis of hepatocellular carcinoma. The potential function of UBE2S in HCC was analyzed by screening UBE2S c

• Autophagy is a dynamic process

  2020-04-15

  

  Autophagy is a dynamic process that primarily involves autophagosome formatting and lysosomal degradation, and these processes are controlled by autophagy-related genes (Atg) (Klionsky et al., 2012). The related protein SQSTM1/p62 (sequestosome 1) importantly serves as a signalling director in sever

• br Materials and methods br Results

  2020-04-15

  

  Materials and methods Results and discussion Conclusions Acknowledgments This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (No. 2011-0030635) and the MarineBio Research Program (NRF-C1ABA001-2011-0018561). The Fonta

• br Restenosis after angioplasty remains a remarkable challen

  2020-04-14

  

  Restenosis after angioplasty remains a remarkable challenge, although drug-eluting stents have reduced the incidence of restenosis considerably . Vascular smooth muscle dan shen (VSMCs) play a pivotal role in the development of intimal thickening and restenosis. VSMCs proliferate and migrate from

• br A brief introduction to DUBs The

  2020-04-14

  

  A brief introduction to DUBs The reversal of ubiquitin conjugation of targeted proteins relies on deubiquitinating AMI5 inhibitor mg (DUBs), which catalytically cleave single Ub or poly-ubiquitin chains from proteins. The human genome encodes approximately 100 potential DUBs which can be classif

• Oxidative stress is associated with elevated levels of

  2020-04-14

  

  Oxidative stress is associated with elevated levels of intracellular reactive oxygen species (ROS) generation which then causes DNA damage and the death of cells (Miyata et al., 2017). Generation of ROS affects main signaling pathways in cells associated with tumorigenesis: mitogen activated protein

• DNA methylation assay To test the biological activity of pur

  2020-04-14

  

  DNA methylation assay. To test the biological activity of purified A1S_0222, a methylation assay was performed using the Int1 DNA. As an alternative DNA substrate, Seq3 (located in gene A1S_0965 of A. baumannii ATCC 17978) was amplified from Acinetobacter baumannii 29D2 using the oligonucleotides Se

• Introduction The Discoidin Domain Receptors DDRs

  2020-04-14

  

  Introduction The Discoidin Domain Receptors (DDRs), comprising DDR1 and DDR2, are collagen-binding receptor tyrosine kinases (RTKs) that function as microenvironmental sensors at the interface of the extracellular matrix and the intracellular signal transduction machinery [1]. In response to ligand

• Cytokines are small secreted proteins that mediate and regul

  2020-04-14

  

  Cytokines are small secreted proteins that mediate and regulate immunity, inflammation, and hematopoiesis. They are produced in response to an immune stimulus. Cytokines regulate the intensity and duration of the immune response by stimulating or inhibiting the activation, proliferation, and/or diff

• br Material and methods br Results br Discussion In

  2020-04-14

  

  Material and methods Results Discussion In the present study, twenty strains of Y. enterocolitica were analyzed for their inhibitory potential on cysteine proteases. Five of these strains belonged to bioserotype 4/O:3, which is distinguished for its pathogenicity towards humans. The rest of

• In solid tumors such as those in breast and pancreatic

  2020-04-14

  

  In solid tumors, such as those in breast and pancreatic cancer, infiltrating CD68+ or CD163+ tumor-associated macrophages (TAMs) correlate with poor outcome (DeNardo et al., 2011, Kurahara et al., 2011, Shabo et al., 2008). The tumor-promoting function of TAMs is based on their capacity to secrete p

• The results of bisaryl ether linker study

  2020-04-14

  

  The results of bisaryl ether linker study are shown in . It was found that the methylene linker () moderately improved the binding to the DP receptor. The increased binding potency was also diminished in the presence of plasma, possibly due to higher plasma protein binding. Other linkers, such as th

• The identification of CRF receptor subtypes has led to

  2020-04-14

  

  The identification of CRF Ranolazine subtypes has led to a number of studies addressing its functional properties. This paper examines the evidence for CRF1 and CRF2 mediation of fear and anxiety. Recent reviews discussing specific CRF receptor functions associated with other conditions including e

14768 records 790/985 page Previous Next First page 上5页 786787788789790 下5页 Last page