• In agreement with our results showing the

  2020-07-30

  

  In agreement with our results showing the presence of CysLT2 receptors in alveolar leukocytes, both CysLT1 and CysLT2 receptors have been reported to be expressed not only in macrophages, but also in eosinophils,19, 21 mast cells, basophils, and dendritic cells. The functional importance of CysLT2 r

• Previous studies demonstrated that cysteinyl LTs

  2020-07-30

  

  Previous studies demonstrated that cysteinyl-LTs can trigger several functional responses in ECs, such as endothelium-dependent relaxation of human saphenous vein [16] or human pulmonary vein [17], increased secretion of von Willebrand factor [18] and PAF accumulation leading to neutrophil adhesion

• br Conclusion br Conflict of interest

  2020-07-30

  

  Conclusion Conflict of interest Prostaglandin D2 (PGD) is the major prostanoid released by mast cells during allergic attacks., In human patients, allergen challenge leads to a rapid increase in the production of PGD in the airway of asthmatics, in the nasal mucosa of allergic rhinitics and

• br CRM and malignancies Cell cycle

  2020-07-30

  

  CRM1 and malignancies Cell cycle regulators and various other anti-neoplastic modulators of cell function that are abnormally exported from the nucleus into the cytoplasm of cancerous cells are, as a result, ancillary targets for CRM1 inhibition (Lapalombella et al., 2012, Inoue et al., 2013, Koj

• The HPA axis controls its own activity through a

  2020-07-30

  

  The HPA axis controls its own activity through a negative feedback mechanism exercised by glucocorticoids (Keller-Wood, 2015), which limits the hypothalamic corticotropin-releasing factor (CRF) secretion and the pituitary BIO-acetoxime release (Keller-Wood, 2015). CRF binds to its specific receptors

• The average deviation using above correlation for the three

  2020-07-30

  

  The average deviation using above correlation for the three Athabasca bitumen mixtures is 7.6%. The computed AARD% using Eq. (13) for each hydrocarbon is very close to one determined by Eq. (11). The results reveal that the proposed correlation of cross association volume parameter follows a reasona

• Our data supports the conclusion that the

  2020-07-29

  

  Our data supports the conclusion that the exonuclease activity thought to be intrinsic to Artemis is not a component of the Artemis polypeptide. Many possibilities exist to explain the presence of the exonuclease activity in less-pure fractions of Artemis. It is possible that the exonuclease is simp

• br Acknowledgements The work was supported by

  2020-07-29

  

  Acknowledgements The work was supported by a grant (D43 TW001503) to D.F.W. from the National Institutes of Health. The authors are very grateful to Dan Milner, Ambroise Ahouidi, Younouss Diedhiou, Lamine Ndiaye, Amadou Mactar Mbaye, Moussa Dieng Sarr, Ngayo Sy, SLAP patients, and the SLAP health

• Type II dehydrogenases are usually monomers or homodimers Th

  2020-07-29

  

  Type II dehydrogenases are usually monomers or homodimers. Their amino phalloidin sequences contain two well conserved motifs to bind nucleotides, one is designated for the noncovalent binding of FAD or FMN, while the second is for NAD(P)H (Kerscher, 2000, Melo et al., 2004, Rasmusson et al., 2004).

• Rats were euthanized with Fatal Plus ml i p

  2020-07-29

  

  Rats were euthanized with Fatal Plus (0.5ml, i.p.; Vortech, Dearborn, MI, USA), brains were removed and fixed in 10% formalin. Brains were sectioned (60μm) on frozen, stained with cresyl violet, and analyzed under light microscope by two experimenters blind to treatment. Only data from rats with can

• br Materials and methods br

  2020-07-28

  

  Materials and methods Results Conclusion Conflict of interest Acknowledgements This work was supported by the National Key Research and Development Program of China (2018YFD0400302) and General Program of National Natural Science Foundation of China (31471602). Introduction A sign

• br Introduction The reticular thalamic nucleus RTn is a

  2020-07-28

  

  Introduction The reticular thalamic nucleus (RTn) is a thin shell of neurons that covers the dorsal thalamus and one of the few thalamic nuclei that does not project to the cerebral cortex. Through GABAergic projections, neurons of the RTn synapse with thalamo-cortical neurons (TCs) and regulate

• br Conflict of interest br Acknowledgment This study was sup

  2020-07-28

  

  Conflict of interest Acknowledgment This study was supported by the grant No. 26071 from Iran University of Medical Sciences. Introduction DNA replication constitutes one of the most important processes within the cell and allows for the accurate duplication of genomic information prior to

• Ligation is the only essential step

  2020-07-28

  

  Ligation is the only essential step in NHEJ and is performed by one of the three mammalian ligases, Niflumic acid IV (LIG4; Wilson et al., 1997). LIG4 is recruited to broken ends through participation in a complex of core NHEJ factors, including XRCC4, the Ku 70/80 heterodimer (Ku; Nick McElhinny e

• Maintenance of genomic integrity is complex due to

  2020-07-28

  

  Maintenance of genomic integrity is complex due to the great diversity of damage that can occur in DNA. Deleterious consequences of damage accumulation may be avoided by a variety of DNA repair pathways, each recognizing and repairing specific types of DNA damage. Base excision repair (BER), nucleot

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