• br The role of P in tumors br The

  2019-04-20

  

  The role of P62 in tumors The role of P62 in osteoclastogenesis P62 as an oncotarget for treatment Concluding remarks P62 is a cellular “Swiss army knife,” with its diverse cellular functions arising from its unique functional motifs and protein–protein interaction properties. P62 may pl

• We conducted a retrospective analysis to

  2019-04-20

  

  We conducted a retrospective analysis to compare a BMD-alone strategy, versus BMD+FRAX® and BMD+FRAX®+TBS screening strategies. To our knowledge, this constitutes the first study to assess the relative contributions of FRAX® and TBS. In our cohort, FRAX®+BMD identified 9 (9%) additional patients at

• ECG changes emerged when creating a substrate map of

  2019-04-20

  

  ECG changes emerged when creating a substrate map of the LV (Fig. 2A), near the inferior mitral valve. A long transseptal sheath was introduced into the LV under intracardiac echocardiography guidance without causing an air-embolism. While performing the LV substrate mapping, the long transseptal sh

• br Material and methods br Results br Discussion PV

  2019-04-20

  

  Material and methods Results Discussion PV isolation is currently the cornerstone for treatment of patients with paroxysmal AF [6]. An extended technique is circumferential PV isolation using point-by-point ablation around the PV ostium. However, that is a technically challenging and time-c

• The exact location of the APs within the cusps

  2019-04-20

  

  The exact location of the APs within the cusps is difficult to determine. The majority of studies used coronary angiography, and less commonly electroanatomical mapping. The morphology of local atrial and ventricular electrograms may be additionally used [1,2]. Mapping within the RCC typically shows

• Before the start of the study we

  2019-04-20

  

  Before the start of the study, we expected referral of up to 3% visceral leishmaniasis cases to the tertiary hospital for management of eventual complications. However, no referral was necessary because all adverse events were mild. Incidence of adverse events was about 47% during treatment and 63%

• In MM the optimal sequence or combination of

  2019-04-20

  

  In MM, the optimal sequence or combination of the different therapeutic regimens available remains unclear and information is needed on the efficacy of each treatment after various prior therapies. Although a substantial number of different regimens and schedules were used for the treatment of first

• In Alexandre de Figueiredo and colleagues take a

  2019-04-20

  

  In , Alexandre de Figueiredo and colleagues take a step in this direction with their time-series analysis of trends in vaccine coverage and a suite of socioeconomic and demographic factors across 190 countries over 30 years. The main aim was to gauge where and when salvinorin coverage might fall bel

• To determine the discriminatory power of the ischiopubic

  2019-04-20

  

  To determine the discriminatory power of the ischiopubic index, the ROC curve was used (Fig. 3). The area under the curve for sex differentiation was 83.5% for the ischiopubic index. In the study N-(p-amylcinnamoyl) with a differentiation point of 100.47°, sensitivity of 82%, specificity of 78%, an

• Los aportes de la escuela francesa constituyen

  2019-04-19

  

  Los aportes de la escuela francesa constituyen su núcleo central. La formación militar de argentinos por franceses data de 1955. En 1957 el coronel Carlos Rosas, egresado de la Escuela Francesa, asumió la subdirección de la Escuela Superior de Guerra y en 1959 se suscribieron una serie de convenios

• The PAX gene encodes a transcriptional factor which

  2019-04-19

  

  The PAX5 gene encodes a transcriptional factor, which is specifically expressed at the early stages of B-cell differentiation and it is required for B-cell development. Its dysregulation is involved in the leukemogenesis of B-ALL. The PAX5 gene rearrangements account for approximately 2.5% of pediat

• br Sustained monomorphic ventricular tachycardia br Monomorp

  2019-04-19

  

  Sustained monomorphic ventricular tachycardia Monomorphic VT is defined as sustained when lasting longer than 30s or requires earlier intervention due to haemodynamic instability [89]. Most commonly, sustained MMVT occurs in the setting of diseased myocardium, but may also be idiopathic, occurr

• Genomic DNA was isolated from blood after

  2019-04-19

  

  Genomic DNA was isolated from blood after obtaining written informed consent. Genetic screening for LQT-1 (KCNQ1), -2 (KCNH2), -3 (SCN5A), -5 (KCNE1), -6 (KCNE2), -7 (KCNJ2), -9 (CAV3), -10 (SCN4B), and -12 (SNTA1) was performed by PCR and direct DNA sequencing. No CEP-37440 was found in these gene

• Introduction Osteosarcoma OS is the most common type

  2019-04-19

  

  Introduction Osteosarcoma (OS) is the most common type of bone tumor occurred in adolescents and children [1]. OS is highly malignant and accounts for about half of bone sarcomas with high potential of metastasis [2]. Treatment for OS is mainly depended on surgical operation, assisted with chemothe

• br Discussion Debate persists about

  2019-04-19

  

  Discussion Debate persists about how to best define the ER ECG pattern. There is consensus regarding definition of the malignant form of ER as a J-point elevation that could be (or not) associated with ST elevation [1]. In this case, a clear J-point elevation was seen, particularly in lead III (F

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