• Dendritic damage and loss of synaptic connections correlate

  2021-10-18

  

  Dendritic damage and loss of synaptic connections correlate with cognitive decline in HAND patients. Synapse loss induced by HIV proteins occurs early and via a different signaling pathway from that leading to neuronal death (Kim et al., 2008), suggesting that synapse loss might be a mechanism to re

• So far GnRH receptors have been

  2021-10-18

  

  So far, GnRH receptors have been detected in the human ovary, but their physiological importance is still unclear (). In particular, GnRH receptors as well as GnRH types I and II have been localized in the granulosa vip receptor of pre-ovulatory follicles, but not of follicles from the primordial t

• A key limiting factor in

  2021-10-18

  

  A key limiting factor in the semi-quantitative analysis of changes in the nuclear-to-cytoplasmic distribution of glucokinase is the large intercellular heterogeneity of 5,8,11-Eicosatriynoic Acid of glucokinase in both isolated hepatocytes in vitro and also in liver in vivo[13], [23], [24], [26], [3

• br Introduction Glucagon is a peptide hormone that acts to

  2021-10-18

  

  Introduction Glucagon is a peptide hormone that acts to increase blood glucose levels. The secretion of glucagon from the alpha hyPerFUsion™ high-fidelity PCR Kit of the islets of Langerhans in the pancreas is increased during fasting and prevents hypoglycemia. Glucagon increases glycogenolysis

• It is generally considered that elevated blood

  2021-10-18

  

  It is generally considered that elevated blood glucose due to insulin resistance is an important factor in islet compensation to high fat feeding [27]. However, we have shown recently that insulin resistance induced in mice by hydrocortisone injection provokes significant islet 2×Taq PCR Master Mix(

• GSIs were shown to effectively

  2021-10-18

  

  GSIs were shown to effectively decrease Aβ levels at doses close to or higher than their IC50 values in cell culture models. Surprisingly, they also slightly increase Aβ levels at low doses, (significantly below the IC50) also known as “Aβ rise”, due to various mechanisms including inhibition of cel

• Considering together the conformational docking and SAR resu

  2021-10-18

  

  Considering together the conformational, docking and SAR results of this and of previously published papers, a three points pharmacophore model can be developed considering the indispensable residues of SRSRY derived antagonists, namely Arg89, Arg91 and Tyr92. This model is shown in Fig. 10, and req

• Bleomycin Sulfate Considering together the conformational do

  2021-10-18

  

  Considering together the conformational, docking and SAR results of this and of previously published papers, a three points pharmacophore model can be developed considering the indispensable residues of SRSRY derived antagonists, namely Arg89, Arg91 and Tyr92. This model is shown in Fig. 10, and req

• Sirolimus rapamycin and everolimus both of which are

  2021-10-16

  

  Sirolimus (rapamycin) and everolimus, both of which are mTOR inhibitors, are released by commonly used first- and second-generation DES. Considering the relatively high rates of the target vessel failure with currently available DES [12,14,16,45,46], there is a need for a novel drug strategy that pr

• br Conflict of interest statement

  2021-10-16

  

  Conflict of interest statement Introduction The Hedgehog (Hh) family of secreted protein signals patterns many tissues and structures during embryogenesis (Chiang et al., 1996, Dessaud et al., 2008, Ingham, 1993) and, post-embryonically, governs tissue homeostasis and regeneration by regulatin

• 221 2 Compounds and were evaluated for their pharmacokinetic

  2021-10-16

  

  Compounds and were evaluated for their pharmacokinetic properties in rats and the results are summarized in . Following intravenous (IV) administration, both compounds displayed low clearance (CL), short half-lives (t) and low volumes of distribution (V). When dosed orally as a solution, exposure

• Several recent studies have linked

  2021-10-16

  

  Several recent studies have linked clock function with the cell cycle and reported that clock components, such as PER1, PER2, BMAL1, and CRY1/2 decrease cell proliferation or improve the action of anti-cancer drugs in different cancer cell lines. Moreover, certain types of human cancer show an alter

• An alternative approach to improving

  2021-10-16

  

  An alternative approach to improving pharmacokinetic profile while retaining high GlyT1 potency was also pursued. Libraries were prepared in which potency enhancing piperidine C4 substituents were combined with clearance lowering truncated alkyl sulfonamides. The result was the discovery of (). Unl

• br Materials and methods br Results br Discussion

  2021-10-16

  

  Materials and methods Results Discussion Ajuba was originally identified as an adaptor protein which communicates cell adhesive events with nuclear responses to remodel the epithelium (Langer et al., 2008; Marie et al., 2003). Recently, increasing evidence has shown that Ajuba functions as

• Rare mutations can impair the

  2021-10-16

  

  Rare mutations can impair the molecular function of GR and alter tissue sensitivity to GCs in humans, resulting in primary generalized GC resistance (PGGR) and hypersensitivity (PGGH) [14]. Familial and sporadic PGGR, or Chrousos Syndrome, is characterized by general and partial insensitivity of tis

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