• Our results might explain the failure

  2020-08-06

  

  Our results might explain the failure of cyclosporine to inhibit in vitro T cell proliferation when it was concomitantly used with dasatinib in experiments performed by Stephen et al. (2012), which showed a reversal of the inhibition of T cell proliferation by cyclosporine and an increase beyond tha

• It is well established that

  2020-08-06

  

  It is well established that Shp-2 can function as a substrate for several RTK, such as PDGF or EGFR [23], [36]. To test whether DDR1 recognizes Shp-2 as its substrate, we overexpressed a catalytically inactive Shp-2 mutant together with DDR1b in 293 cells [31]. Immunoprecipitation of Shp-2 followed

• Many filarial species harbor an endosymbiotic bacterium

  2020-08-06

  

  Many filarial species harbor an endosymbiotic bacterium of the genus Wolbachia. A recent investigation of Wolbachia distribution in 35 filarial species including 28 species and 7 genera and/or subgenera have shown that 37% of them harbor Wolbachia (Ferri et al., 2011). In filarial nematodes, Wolbach

• NS 11394 br Summary and discussion Our results suggest

  2020-08-06

  

  Summary and discussion Our results suggest that, counter to Marques (2012), the creation of a successful accelerated program does not require a fundamental shift in the manner of pedagogy. This may help to overcome faculty objections to accelerated teaching. It is also important to note that our

• Furthermore several T cell epitopes have been identified

  2020-08-06

  

  Furthermore, several T cell epitopes have been identified based on the notion that the P4 pocket of RA-associated HLA-DR PPM-18 receptor cannot accommodate a positively charged arginine side chain but can fit a neutral citrulline [25]. However, a growing list of citrulline-specific T cell epitopes

• Our previous studies have demonstrated that the DDR discoidi

  2020-08-05

  

  Our previous studies have demonstrated that the DDR2 discoidin domain fully contains the binding site(s) for the fibrillar collagens I and II (Leitinger, 2003, Leitinger et al., 2004). The binding site for collagen I was mapped to three spatially adjacent surface loops within the DDR2 discoidin doma

• Because the E enzyme directly recognizes a

  2020-08-05

  

  Because the E2 enzyme directly recognizes a SCM, it can modify substrates in vitro at high enzyme concentrations as we illustrate in Fig. 1A. Hence, it is important to use a low E2 concentration in E3-dependent reactions that either show no or only marginal substrate modification by the E2 alone. At

• br Acknowledgments Our work introduced in this review was pa

  2020-08-05

  

  Acknowledgments Our work introduced in this review was partially supported by Precursory Research for Embryonic Science and Technology (PRESTO, Japan Science and Technology Agency JST), Grant-in-Aid for Challenging Exploratory Research (Japan Society for the Promotion of Science) (15K14239), and

• br Data availability br Acknowledgments

  2020-08-05

  

  Data availability Acknowledgments The work was supported in Department of Biochemistry by grants from British Heart Foundation (SP/15/7/31561, FS/15/20/31335 and RG/15/4/31268). At the Department of Materials Science, Cambridge, funding was from the People Programme of the EU 7th Framework Pro

• br Acknowledgement AM and SK thank ICMR New

  2020-08-05

  

  Acknowledgement AM and SK thank ICMR, New Delhi, India for the financial assistance BIC/12(32)/2012. SK is the recipient of JRF from the project. RK and GJ thank Bristol-Myer Squibb (Grant # 34003085), USA for financial support. Introduction Proliferating Cell Nuclear Antigen (PCNA) is a high

• Although most jawed vertebrates typically possess

  2020-08-05

  

  Although most jawed vertebrates typically possess both CXCR1 and CXCR2, teleost CXCR1 and CXCR2 are not 1:1 orthologues to their tetrapod counterparts (Saha et al., 2007). Several hypotheses have been proposed regarding how these receptors have evolved during vertebrate evolution. It is believed tha

• br Results br Discussion Many studies have shown that

  2020-08-04

  

  Results Discussion Many studies have shown that intrinsic properties of the E2 enzyme govern the nature of the Ub modification, including both the multiplicity of the Ub modification and the specific RSL3 australia type in the case of polyubiquitin chains [3], [4], [9], [14]. Whereas previous

• Industrial fermentation aims to produce

  2020-08-04

  

  Industrial fermentation aims to produce valuable products from cheap feedstocks by utilizing diverse microbial functions through aerobic or anaerobic fermentation [[8], [9], [10]]. During anaerobic fermentation, the reducing power is mostly directed to product synthesis rather than being oxidized, r

• Independently of these studies of cellular genes our group h

  2020-08-04

  

  Independently of these studies of cellular genes, our group has investigated how methylation affects HPV genomes in different stages of cervical neoplastic disease (Kalantari et al., 2004, Kalantari et al., 2008a, Kalantari et al., 2010, Badal et al., 2004, Turan et al., 2006, Turan et al., 2007), a

• Several studies have already shown

  2020-08-04

  

  Several studies have already shown that mPR activation can significantly reduce intracellular cAMP levels in different kind of cells, such as GT1-7 neuronal cells [32], MDA-MB-468 breast cancer cells [55] and primary vascular endothelial cells [56]. The experiments performed with PTXa and 8-Br-cAMP

15442 records 781/1030 page Previous Next First page 上5页 781782783784785 下5页 Last page